Reaktion #534491

Reaktionsgleichung

4-(4-isopropylpiperazin-1-yl)phenylboronic acid

4-(1-(4-bromophenyl)piperidin-4-yl)morpholine

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title compound

Ausbeute 40.0%

4-(4-morpholinopiperidin-1-yl)phenylboronic acid

Ausbeute 40.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was synthesized
2. 2
   WaschenThe aqueous layer was washed with EtOAc
3. 3
   Einengenconcentrated
4. 4
   SonstigeThe residue was triturated with THF
5. 5
   Einengenthe filtrate was concentrated

Vorschrift

The title compound was synthesized according to the synthesis of 4-(4-isopropylpiperazin-1-yl)phenylboronic acid, except substituting 4-(1-(4-bromophenyl)piperidin-4-yl)morpholine (250 mg, 0.77 mmol). The aqueous layer was washed with EtOAc and concentrated. The residue was triturated with THF and the filtrate was concentrated to give the title compound as a yellow solid (87 mg, 40%). 1H NMR (400 MHz, MeOD) δ 7.58 (br s, 2H), 6.93 (d, J=7.5 Hz, 2H), 3.85-3.82 (m, 2H), 3.72 (br s, 4H), 2.72 (t, J=12.3 Hz, 2H), 2.63 (br s, 4H), 2.40-2.34 (m, 1H), 2.01-1.98 (m, 2H), 1.62-1.54 (m, 2H); MS ESI 291.1 [M+H]+, calcd for [C15H23BN2O3+H]+ 291.18.

Quelle