Reaktion #53447

Reaktionsgleichung

N-[4-bromo-2-fluorophenyl]-3,3-dichlorocaprolactam

morpholine

→

1,5,6,7-tetrahydro-1-[4-bromo-2-fluorophenyl]-3-(morpholin-4-yl)-2H-azepin-2-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was then removed in vacuo
2. 2
   workup.ADDITIONToluene was added
3. 3
   Filtrationthe solid was filtered off
4. 4
   EinengenThe filtrate was concentrated
5. 5
   Sonstigedried under vacuum

Vorschrift

N-[4-bromo-2-fluorophenyl]-3,3-dichlorocaprolactam (0.49 g, 1.38 mmol) was refluxed with 10 mL of morpholine under N2 for 1 h. The solvent was then removed in vacuo. Toluene was added and the solid was filtered off. The filtrate was concentrated and dried under vacuum to give 1,5,6,7-tetrahydro-1-[4-bromo-2-fluorophenyl]-3-(morpholin-4-yl)-2H-azepin-2-one as brown oil (0.55 g). LRMS (AP+): 369.0, 371.0, (M+H)+.

Quelle