Reaktion #534288

Reaktionsgleichung

hydrazine

4,5,6,7-tetrahydro-isobenzofuran-1,3-dione

→

2,3,5,6,7,8-hexahydro-phthalazin-1,4-dione

Ausbeute 96.0%

Lösungsmittel

water

HOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is refluxed for 3 h
2. 2
   Filtrationthe precipitate is collected by filtration
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried under vacuum

Vorschrift

To a solution of hydrazine (392 μL, 13.1 mmol) in water (6 mL) and HOAc (2 mL) is added 4,5,6,7-tetrahydro-isobenzofuran-1,3-dione (2 g, 13.1 mmol). The reaction mixture is refluxed for 3 h, then cooled down to room temperature and the precipitate is collected by filtration, washed with water and dried under vacuum to give 2,3,5,6,7,8-hexahydro-phthalazin-1,4-dione (40) (2.09 g, 96%).

Quelle