Reaktion #534264

Reaktionsgleichung

(R)-1-boc-methylpiperazine

5-chloro-pyrazine-2-carboxylic acid methyl ester

Na2CO3

→

(R)-2-Methyl-4-boc-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-5′-carboxylic acid methyl ester

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThen the mixture is cooled to rt
2. 2
   Sonstigethe organic solvent is removed in vacuo
3. 3
   Sonstigeto afford a brown colored solid as product (1.7 g, quant.)

Vorschrift

To (R)-1-boc-methylpiperazine (1 g, 5.0 mmol) in DMF (20 mL) is added 5-chloro-pyrazine-2-carboxylic acid methyl ester (862 mg, 5.0 mmol) and Na2CO3 (2.1 g, 20.0 mmol). The reaction mixture is stirred in a microwave reactor at 140° C. for 3 h. Then the mixture is cooled to rt and the organic solvent is removed in vacuo to afford a brown colored solid as product (1.7 g, quant.).

Quelle