Reaktion #5337

Reaktionsgleichung

syrup

Methyl 3-amino-2-[[2'-(ethoxycarbonyloxycarbamimidoyl)biphenyl-4-yl]methylamino]benzoate

tetraethoxymethane

acetic acid

→

title compound

Methyl 2-ethoxy-1-[[2'-(ethoxycarbonyloxy-carbamimidoyl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated to dryness
2. 2
   SonstigeThe residue was crystallized from ethyl acetate (50 ml)
3. 3
   SonstigeResulting crystalline precipitates
4. 4
   Filtrationwere collected by filtration

Vorschrift

The pale brown syrup (8.58 g) obtained in Example (57a) was dissolved in dioxane (20 ml). To the solution were added tetraethoxymethane (8.64 g) and acetic acid (1.56 g). The mixture was stirred for 2 hours at 100° C. The reaction mixture was concentrated to dryness. The residue was crystallized from ethyl acetate (50 ml). Resulting crystalline precipitates were collected by filtration to obtain the title compound.

Quelle