Reaktion #533446

Reaktionsgleichung

2-Amino-4-tert-pentylphenol

potassium carbonate

Methyl iodide

→

title compound

2-(methylamino)-4-tert-pentylphenol

Lösungsmittel

DMF

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with aqueous sodium bicarbonate and water
2. 2
   TrocknenDried the organic layers over sodium sulfate
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated
5. 5
   Sonstigepurified by silica gel chromatography (10-15% MTBE/hexanes)
6. 6
   EinengenConcentrated the product fractions

Vorschrift

2-Amino-4-tert-pentylphenol (5.00 g, 27.8 mmol) and potassium carbonate (3.88 g, 28.1 mmol) were mixed at RT for 2.5 hours in DMF (15 mL). Methyl iodide (1.20 mL, 19.3 mmol) was added and the mixture was stirred overnight at RT. Diluted the mixture with EtOAc and extracted with aqueous sodium bicarbonate and water. Dried the organic layers over sodium sulfate, filtered, concentrated and purified by silica gel chromatography (10-15% MTBE/hexanes). Concentrated the product fractions to yield the title compound.

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