Reaktion #533431

Reaktionsgleichung

1-[2-(2-Nitro-4-trifluoromethyl-phenoxy)-ethyl]-pyrrolidine

→

desired product

2-(2-Pyrrolidin-1-yl-ethoxy)-5-trifluoromethyl-phenylamine

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeH2 gas was bubbled through the solution, which
2. 2
   SonstigeAfter completion of the reaction by LCMS
3. 3
   Filtrationthe mixture was filtered through celite
4. 4
   Einengenconcentrated

Vorschrift

To a solution of 1-[2-(2-Nitro-4-trifluoromethyl-phenoxy)-ethyl]-pyrrolidine (1.70 g, 5.59 mmol) in dry MeOH (56 mL) was added Pd/C (10%, 350 mg). H2 gas was bubbled through the solution, which was then stirred vigorously under an atmosphere of H2. After completion of the reaction by LCMS, the mixture was filtered through celite and concentrated to afford the desired product as a yellow/orange oil. MS (M+H)+=275; Calc'd 274.29 for C13H17F3N2O.

Quelle