Reaktion #533391

Reaktionsgleichung

Methyl 6-bromo-2-naphthoate

diisobutyl aluminum hydride

Sodium bicarbonate

→

solid

Ausbeute 96.0%

(6-bromonaphthalene-2-yl)methanol

Ausbeute 96.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was removed by extraction with water and dichloromethane
2. 2
   SonstigeThe extracted material was dried in vacuum

Vorschrift

Methyl 6-bromo-2-naphthoate (5 g, 18.9 mmol) was dissolved in purified THF (100 mL) under a nitrogen atmosphere, the reaction solution was cooled down to 0° C., and then diisobutyl aluminum hydride (18.9 mL, 1.0M hexane solution) was added thereto. The reaction mixture solution was stirred at room temperature for 3 hours. Sodium bicarbonate (20 mL) was added to the reaction mixture solution, and then the solvent was removed by extraction with water and dichloromethane. The extracted material was dried in vacuum to thereby obtain a white solid (4.3 g, yield: 95%).

Quelle