Reaktion #5333

Reaktionsgleichung

methyl 3-iodobenzoate

toluene

→

title compound

Ausbeute 29.0%

Methyl 4'-methylbiphenyl-3-carboxylate

Ausbeute 29.0%

Lösungsmittel

4-iodotoluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationInsoluble materials were filtered off
2. 2
   Einengenthe filtrate was concentrated to dryness
3. 3
   SonstigeThe residue was purified by column chromatography on silica gel

Vorschrift

To a mixture of methyl 3-iodobenzoate (26.1 g) in 4-iodotoluene (21.9 g) was added copper powder (31.8 g) gradually at 180°-190° C. The mixture was then stirred for 6 hours at 200°-210° C. The reaction mixture was cooled to room temperature, to which was added toluene. Insoluble materials were filtered off, and the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (6.61 g, 29%).

Quelle