Reaktion #533094

ord-2ed164214171428287188210e66bb688

Reaktionsgleichung

N=C(N)NCCC[C@H](N)C(=O)O
L-arginine
C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
tazobactam acid
→
C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O.N=C(N)NCCC[C@H](N)C(=O)O
tazobactam arginine
Ausbeute 101.3%

Edukte

N=C(N)NCCC[C@H](N)C(=O)O
L-arginine
C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
tazobactam acid

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeresulting a homogenous solution

Vorschrift

L-arginine (2.9 g) was dissolved in 100 mL of deionized water and 5.0 g of tazobactam acid was then added, resulting a homogenous solution. The solution was lyophilized overnight to yield tazobactam arginine amorphous as an off-white solid (8.0 g). The XRPD spectrum of the tazobactam arginine amorphous is depicted in FIG. 5.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08476425B1uspto-grants-2013_07