Reaktion #53309

Reaktionsgleichung

Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxobutyrate

bromine

→

title compound

Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxo-3-bromobutyrate

Lösungsmittel

ether

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereaction mixture
2. 2
   Einengenwas concentrated
3. 3
   Sonstigepurified by flash chromatography on silica gel column (EtOAc:Hex, 1:4)

Vorschrift

To a ice cooled solution of Ethyl 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxobutyrate (Step C, 3 g, 9 mmol) in dry ether (70 ml) was added dropwise bromine (0.7971 g, 9.9 mmol) diluted in ether (30 ml). After 4 hours of stirring, reaction mixture was concentrated and purified by flash chromatography on silica gel column (EtOAc:Hex, 1:4) to provide the title compound.

Quelle