Reaktion #532994

Reaktionsgleichung

2-chlorocyclopentanone

ethyl 2-bromo-4-chlorophenol

potassium carbonate

→

2-(2-bromo-4-chlorophenoxy)cyclopentanone

Ausbeute 71.0%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through celite
2. 2
   Einengenconcentrated in vacuo
3. 3
   Sonstigepurified by flash chromatography on silica gel (20% EtOAc in hexanes)

Vorschrift

To a solution of ethyl 2-bromo-4-chlorophenol (10.9 g, 52.5 mmol) in acetone (105 mL) was added potassium carbonate (14.5 g, 105 mmol), followed by 2-chlorocyclopentanone (6.3 mL, 63 mmol). The mixture was refluxed at 100° C. overnight, then filtered through celite, concentrated in vacuo and purified by flash chromatography on silica gel (20% EtOAc in hexanes) to provide 2-(2-bromo-4-chlorophenoxy)cyclopentanone (516B) (10.8 g, 71.0%) as a yellow oil.

Quelle