Reaktion #53295

Reaktionsgleichung

4-Hydroxybenzyl cyanide

K2CO3

2,6-Difluorobenzyl bromide

→

title compound

(4-(2,6-Difluorobenzyloxy)phenyl)-acetonitrile

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   Waschenwashed with water and brine
3. 3
   WaschenThe aqueous layer was washed one more time with EtOAc
4. 4
   TrocknenThe combined organic layers were dried over Na2SO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated

Vorschrift

To a solution of 4-Hydroxybenzyl cyanide (5 g, 37.5 mmol) and K2CO3 (6.74 g, 48.8 mmol) in dry DMF (20 ml) was added 2,6-Difluorobenzyl bromide (7.77 g, 37.5 mmol). The reaction mixture was stirred for 4 hours at room temperature and concentrated in vacuo. The crude residue was taken in EtOAc and washed with water and brine. The aqueous layer was washed one more time with EtOAc. The combined organic layers were dried over Na2SO4 filtered, and concentrated to provide the title compound as a white solid.

Quelle