Reaktion #53286

Reaktionsgleichung

2-Fluorobenzyl methanesulfonate

2-(Methylamino)-ethanol

→

title compound

2-(N-(2-fluorobenzyl)-N-methylamino)-ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to room temperature
2. 2
   Einengenconcentrated
3. 3
   SonstigeThe crude residue was purified by flash chromatography on silica gel column (chloroform:methanol, 90:10 spiked with triethylamine)

Vorschrift

A mix of 2-Fluorobenzyl methanesulfonate (Step A, 5 g, 24.5 mmol) and 2-(Methylamino)-ethanol (18.4 g, 244.9 mmol) was heated under argon at 120° C. with stirring for 7 hours. The mixture was cooled to room temperature and concentrated. The crude residue was purified by flash chromatography on silica gel column (chloroform:methanol, 90:10 spiked with triethylamine) to provide the title compound.

Quelle