Reaktion #532761

Reaktionsgleichung

8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

Intermediate A

8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

2-[3-methoxy-4-(2-methoxy-ethoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

→

title compound

1-(1,3-Dimethyl-1H-pyrazol-4-yl)-8-[3-methoxy-4-(2-methoxy-ethoxy)-phenyl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was synthesized in a similar manner

Vorschrift

The title compound was synthesized in a similar manner as described for Example 1.1 using 8-bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one (Intermediate A, 39 mg, 0.105 mmol) and 2-[3-methoxy-4-(2-methoxy-ethoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (Stage 30.1.1, 39 mg, 0.126 mmol) to give the title compound as a white solid. (HPLC: tR 2.71 min (Method A); M+H=474 MS-ES; 1H-NMR (d6-DMSO, 400 MHz) 8.93 (s, 1H), 8.15-8.02 (m, 2H), 7.97-7.89 (m, 1H), 7.59-7.51 (m, 1H), 7.11-7.02 (m, 2H), 7.00-6.94 (m, 1H), 4.16-4.07 (m, 2H), 3.94-3.84 (m, 6H), 3.70-3.64 (m, 2H), 3.58 (s, 3H), 3.31 (s, 3H), 1.97 (s, 3H))

Quelle