Reaktion #53241

Reaktionsgleichung

guanidine carbonate

ethyl acetoacetate

→

6-methyl-iso cytosine

Ausbeute 125.6%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction solution was gradually heated
2. 2
   Temperaturto reflux temperature
3. 3
   SonstigeEthanol (300 mL) was evaporated
4. 4
   Temperaturthe reaction mixture was heated
5. 5
   Temperaturunder reflux for two hours
6. 6
   TemperaturAfter the reaction mixture was cooled
7. 7
   workup.ADDITION300 mL of hexane was added
8. 8
   FiltrationThe resulting precipitate was filtered
9. 9
   Waschenwashed
10. 10
    Sonstigedried

Vorschrift

Dry ethanol (600 mL), 91.89 g of guanidine carbonate, and 146.1 g of ethyl acetoacetate were added to a 1 L flask. The reaction solution was gradually heated to reflux temperature and stirred overnight. Ethanol (300 mL) was evaporated, and the reaction mixture was heated under reflux for two hours. After the reaction mixture was cooled, 300 mL of hexane was added. The resulting precipitate was filtered, washed and dried. 119.3 g of 6-methyl-iso cytosine was obtained.

Quelle