Reaktion #532245

Reaktionsgleichung

8-(2,5-dimethoxy-phenylsulfanyl)-9H-purin-6-ylamine

1-(2-bromo-ethyl)-2-fluoro-benzene

→

8-(2,5-Dimethoxy-phenylsulfanyl)-3-[2-(2-fluoro-phenyl)-ethyl]-3H-purin-6-ylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe isomers were separated by preparative HPLC

Vorschrift

The title compounds were prepared from 8-(2,5-dimethoxy-phenylsulfanyl)-9H-purin-6-ylamine and 1-(2-bromo-ethyl)-2-fluoro-benzene by a procedure similar to examples 1 and 2. The isomers were separated by preparative HPLC. 8-(2,5-Dimethoxy-phenylsulfanyl)-9-[2-(2-fluoro-phenyl)-ethyl]-9H-purin-6-ylamine: Yield 37%, 1H NMR (DMSO-d6) δ 8.27 (s, 1H), 7.28-7.22 (m, 1H), 7.12-7.00 (m, 4H), 6.87 (dd, J=8.8, 3.2 Hz, 1H), 6.55 (d, J=3.2 Hz, 1H), 4.45 (t, J=6.8, Hz, 2H), 3.72 (s, 3H), 3.62 (s, 3H), 3.08 (t, J=6.8, 2H); LC-MS [M+H]+ 426.1. 8-(2,5-Dimethoxy-phenylsulfanyl)-3-[2-(2-fluoro-phenyl)-ethyl]-3H-purin-6-ylamine: Yield, 18%, 1H NMR (DMSO-d6) δ 8.37 (s, 1H), 8.19 (bs, 2H), 7.33-7.08 (m, 7H), 4.55 (t, J=7.2 Hz, 2H), 3.76 (s, 3H), 3.73 (s, 3H), 3.23 (t, J=7.2 Hz, 2H); LC-MS [M+H]+ 426.1.

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