Reaktion #53217

Reaktionsgleichung

isopropylsulphonic acid chloride

4-tert.butoxycarbonylamino-aniline

→

isopropylsulphonic acid-(4-tert.butoxycarbonylamino-phenyl)-amide

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   WaschenThe organic phases are washed with water
3. 3
   SonstigeThe residue is chromatographed on silica gel (dichloromethane/methanol/NH4OH=19:1:0.1)

Vorschrift

1.2 g (10 mmol) of isopropylsulphonic acid chloride are added dropwise to a solution of 1.0 g (4.8 mmol) of 4-tert.butoxycarbonylamino-aniline in 10 ml of pyridine. The mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is poured onto 150 ml of ice water and then extracted with ethyl acetate. The organic phases are washed with water and freed from solvent. The residue is chromatographed on silica gel (dichloromethane/methanol/NH4OH=19:1:0.1).

Quelle