Reaktion #53211

Reaktionsgleichung

dimethylamine

4-[3-(p-tolylsulphonyloxy)-prop-1-ynyl]-nitrobenzene

→

4-(3-dimethylaminoprop-1-ynyl)-nitrobenzene

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThen the reaction solution is washed with water
2. 2
   SonstigeThe residue is chromatographed on silica gel (dichloromethane/methanol=10:1)
3. 3
   SonstigeThe product is obtained as an oil

Vorschrift

190 ml (4.2 mmol) of dimethylamine dissolved in 2.5 ml of dichloromethane are added dropwise at 0° C. to a solution of 0.7 g (2.1 mmol) of 4-[3-(p-tolylsulphonyloxy)-prop-1-ynyl]-nitrobenzene in 10 ml of dichloromethane. The cooling is stopped and the mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is washed with water and freed from solvent. The residue is chromatographed on silica gel (dichloromethane/methanol=10:1). The product is obtained as an oil.

Quelle