Reaktion #53198

Reaktionsgleichung

methylamine

4-(2-bromoethyl)-nitrobenzene

hydrochloric acid

→

4-(2-methylamino-ethyl)-nitrobenzene

Lösungsmittel

dichloromethane

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile cooling with ice
2. 2
   Sonstigeto come up slowly to ambient temperature
3. 3
   Waschenthe mixture is washed with dichloromethane
4. 4
   Extraktionthe product is extracted with dichloromethane

Vorschrift

2.7 g (86 mmol) of methylamine are dissolved in 120 ml of dichloromethane while cooling with ice. 4.9 g (21 mmol) of 4-(2-bromoethyl)-nitrobenzene are added and the mixture is allowed to come up slowly to ambient temperature. After 15 hours stirring the solvent is eliminated in vacuo and the residue taken up in water. An acid pH is created using 2 N hydrochloric acid and the mixture is washed with dichloromethane. The aqueous phase is then adjusted to a basic pH using 4 N sodium hydroxide solution and the product is extracted with dichloromethane.

Quelle