Reaktion #53193

ord-156a85ae9e3e470a9c24e206feff8c55

Reaktionsgleichung

CC(=O)N1C(=O)C(=C(Cl)c2cccc(Cl)c2)c2ccccc21
1-acetyl-3-[1-chloro-1-(3-chlorophenyl)-methylidene)-2-indolinone
CN(C)Cc1ccc(N)cc1
4-dimethylaminomethyl-aniline
[Na+].[OH-]
sodium hydroxide
→
CN(C)Cc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2cccc(Cl)c2)cc1
(Z)-3-[1-(4-dimethylaminomethyl-phenylamino)-1-(3-chlorophenyl)-methylidene]-2-indolinone

Edukte

CC(=O)N1C(=O)C(=C(Cl)c2cccc(Cl)c2)c2ccccc21
1-acetyl-3-[1-chloro-1-(3-chlorophenyl)-methylidene)-2-indolinone
CN(C)Cc1ccc(N)cc1
4-dimethylaminomethyl-aniline
[Na+].[OH-]
sodium hydroxide

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF
CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 2 from 1-acetyl-3-[1-chloro-1-(3-chlorophenyl)-methylidene)-2-indolinone and 4-dimethylaminomethyl-aniline in DMF and subsequent treatment with sodium hydroxide solution in methanol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06855710B2uspto-grants-2005_02