Reaktion #531900

Reaktionsgleichung

β-CD

water

trans-resveratrol

→

trans-resveratrol β-cyclodextrin

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated to a temperature
2. 2
   Temperaturthe mixture was heated again twice to a temperature
3. 3
   workup.WAITranging 60-70° C. in a microwave oven, for 90 seconds
4. 4
   workup.ADDITIONwere added
5. 5
   TemperaturThe mixture was heated once or twice to a temperature
6. 6
   workup.WAITranging 60-70° C. in a microwave oven, for 90 seconds
7. 7
   workup.WAITleft at this temperature up to 24 hours

Vorschrift

Fifty g of β-CD (44 mM) and 1000 mL of distilled water were put in a 5000 mL beaker. The mixture was heated to a temperature ranging 60-70° C. in a microwave oven, for 90 seconds. Soon after, 100 to 200 mL of ethanol 96% were added, and the mixture was heated again twice to a temperature ranging 60-70° C. in a microwave oven, for 90 seconds. To the resulting solution, 10 g of trans-resveratrol (44 mM) diluted in 50-100 mL of ethanol 96% were added. The mixture was heated once or twice to a temperature ranging 60-70° C. in a microwave oven, for 90 seconds. The resulting solution was slowly cooled at 15° C. and left at this temperature up to 24 hours. The crystals formed from trans-resveratrol/β-cyclodextrin (β-CD/Res) complex were collected by filtration under reduced pressure, and dried in a vacuum oven at 60° C., resulting in 14.5-28 g of the invention complex with purity from 91 to 98% and a yield around 56%. Besides, filtrate (resulting solution) was freeze dried, providing 45.5-31.5 g of solid material having non-reacted components and other complexes (FIGS. 1 and 6).

Quelle