Reaktion #531893

Reaktionsgleichung

4-benzyloxycarbonylamino-cyclohexanecarboxylic acid tert-butyl ester

hydrogen

→

4-amino-cyclohexanecarboxylic acid tert-butyl ester

Ausbeute 100.3%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture is then filtered though celite
2. 2
   WaschenThe celite is washed with MeOH (50 mL)
3. 3
   EinengenThe filtrated is concentrated

Vorschrift

To a solution of 4-benzyloxycarbonylamino-cyclohexanecarboxylic acid tert-butyl ester (3.0 g, 9.009 mmol) in THF (80 mL) is added TEA (0.24 mL, 1.724 mmol) and 10% Pd/C (wet) (420 mg). The mixture stirs under a blanket of hydrogen gas at atmospheric pressure for 12 h. The mixture is then filtered though celite. The celite is washed with MeOH (50 mL). The filtrated is concentrated to afford 1.8 g of 4-amino-cyclohexanecarboxylic acid tert-butyl ester. LC/MS: [M+H]+ 200, Rt=0.39 min (method 6).

Quelle