Reaktion #531889

Reaktionsgleichung

azaproline

MeCN

phenylisocyanate

→

phenylurea

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthen concentrated in vacuo
2. 2
   SonstigeThe crude residue was purified by silica gel chromatography (ethyl acetate-hexanes)

Vorschrift

To a solution of azaproline VI (20.0 mg, 0.056 mmol) and TEA (9.5 pt, 0.068 mmol) in DCM (400 μL)/MeCN (750 μL) was added phenylisocyanate (7.3 μL, 0.067 mmol). The solution was stirred at rt for 16 h then concentrated in vacuo. The crude residue was purified by silica gel chromatography (ethyl acetate-hexanes) to afford 18.9 mg of phenylurea in 71% yield. LCMS (M+1): 474.84.

Quelle