Reaktion #531790

Reaktionsgleichung

Mercaptopropionic acid

Triphenylmethylchloride

→

3-(tritylthio)propanoic acid

Ausbeute 95.7%

3-(tritylthio) propanoic acid

Ausbeute 95.7%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewere carried out at room temperature
2. 2
   Filtrationwas filtered
3. 3
   Waschenwas rinsed with 40 ml of diethyl ether
4. 4
   SonstigeThe precipitate was then dried under reduced pressure

Vorschrift

Mercaptopropionic acid 2 (3.14 g) was dissolved in 50 ml of methylene chloride. Triphenylmethylchloride 3 (8.36 g, 30 mmol) was added to that, and 19-hour protection reactions were carried out at room temperature. The precipitate generated through the protection reactions was filtered and gathered, and was rinsed with 40 ml of diethyl ether. The precipitate was then dried under reduced pressure, to form 9.86 g of 3-(tritylthio)propanoic acid 4, which is a white solid.

Quelle