Reaktion #531521

Reaktionsgleichung

hydrogen

1-benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-3-hydroxypiperidine

→

title compound

Ausbeute 70.0%

3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-3-piperidinol

Ausbeute 70.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 8.5 g
2. 2
   FiltrationThe reaction mixture is filtered through diatomaceous earth with ethyl acetate
3. 3
   Sonstigeevaporated
4. 4
   SonstigeThe residue is recrystallized from ethyl acetate
5. 5
   Sonstigeto yield 3.8 g

Vorschrift

A mixture of 8.5 g. (17.03 mmols) of 1-benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-3-hydroxypiperidine, 2.0 g. of 10% palladium-on-carbon and 60 ml. of ethanol is stirred under one atmosphere of hydrogen for 2 hours. The reaction mixture is filtered through diatomaceous earth with ethyl acetate and evaporated. The residue is recrystallized from ethyl acetate to yield 3.8 g. (70%) of the title compound. A second crop of the title compound 0.396 g. (7%) is obtained from the mother liquor.

Quelle