Reaktion #5310

Reaktionsgleichung

Dihydropyran

4-chlorobutanol

→

title compound

Ausbeute 89.9%

2-[(4-Chlorobutyl)oxy]tetrahydropyran

Ausbeute 89.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
2. 2
   TemperaturThe dried liquid was heated under reduced pressure

Vorschrift

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

Quelle