Reaktion #5308

Reaktionsgleichung

H2O

NaH

2-methoxybenzenebutanol

1,6-dibromohexane

→

title compound

Ausbeute 58.8%

1-[4-[(6-Bromohexyl)oxy]butyl]-2-methoxybenzene

Ausbeute 58.8%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe suspension was refluxed for 20 h
2. 2
   ExtraktionThe resulting emulsion was extracted with ER (2×50 ml)
3. 3
   Extraktionthe dried extract
4. 4
   Sonstigewas evaporated
5. 5
   Sonstigeto leave a yellow oil
6. 6
   SonstigeThe oil was purified on a column of silica (Merck 9385, 600 ml) [A]

Vorschrift

NaH (46% dispersion in oil; 1.36 g) was added portionwise to a solution of 2-methoxybenzenebutanol (5.0 g) and 1,6-dibromohexane (13.8 g) in THF (50 ml). The suspension was refluxed for 20 h and was treated cautiously with H2O (20 ml). The resulting emulsion was extracted with ER (2×50 ml) and the dried extract was evaporated to leave a yellow oil. The oil was purified on a column of silica (Merck 9385, 600 ml) [A] to give the title compound as a colourless oil (5.6 g). T.l.c. [B] Rf 0.2.

Quelle