Reaktion #53076

Reaktionsgleichung

1-acetyl-3-(1-methoxy-1-phenyl-methylidene)-5-nitro-2-indolinone

4-chloroaniline

ammonia

→

(Z)-3-[1-(4-chlorophenylamino)-1-phenyl-methylidene]-5-nitro-2-indolinone

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred for 48 hours
2. 2
   SonstigeAfter removal of the solvent in vacuo the residue
3. 3
   Sonstigeis triturated with ether, suction
4. 4
   Filtrationfiltered
5. 5
   Sonstigedried

Vorschrift

0.5 g (1.5 mmol) of 1-acetyl-3-(1-methoxy-1-phenyl-methylidene)-5-nitro-2-indolinone are dissolved in 20 ml of dichloromethane and after the addition of 0.57 g (4.5 mmol) of 4-chloroaniline stirred for 72 hours at ambient temperature. Then 3 ml of methanolic ammonia are added and stirred for 48 hours. After removal of the solvent in vacuo the residue is triturated with ether, suction filtered and dried.

Quelle