Reaktion #53029

ord-500f6ec9cb79437a9920a08711356f52

Reaktionsgleichung

O=C1Nc2ccccc2/C1=C(/Nc1cccc(C(=O)O)c1)c1ccccc1
(Z)-3-[1-(3-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone
CN.Cl
methylamine-hydrochloride
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
On1nnc2ccccc21
HOBt
→
CNC(=O)c1cccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)c1
(Z)-3-[1-(3-methylaminocarbonyl-phenylamino)-1-phenyl-methylidene]-2-indolinone

Edukte

O=C1Nc2ccccc2/C1=C(/Nc1cccc(C(=O)O)c1)c1ccccc1
(Z)-3-[1-(3-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone
CN.Cl
methylamine-hydrochloride
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
On1nnc2ccccc21
HOBt

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF
CCN(CC)CC
triethylamine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 18 from (Z)-3-[1-(3-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone, methylamine-hydrochloride, TBTU, HOBt and triethylamine in DMF.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06855710B2uspto-grants-2005_02