Reaktion #53027

ord-e3ae603ae8a94acf81fde332878092f2

Reaktionsgleichung

O=C1Nc2ccccc2/C1=C(/Nc1ccc(C(=O)O)cc1)c1ccccc1
(Z)-3-[1-(4-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone
CN.Cl
methylamine-hydrochloride
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
On1nnc2ccccc21
HOBt
CCN(C(C)C)C(C)C
N-ethyl-N,N-diisopropylamine
→
CNC(=O)c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1
(Z)-3-[1-(4-methylaminocarbonyl-phenylamino)-1-phenyl-me-thylidene]-2-indolinone

Edukte

O=C1Nc2ccccc2/C1=C(/Nc1ccc(C(=O)O)cc1)c1ccccc1
(Z)-3-[1-(4-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone
CN.Cl
methylamine-hydrochloride
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
On1nnc2ccccc21
HOBt
CCN(C(C)C)C(C)C
N-ethyl-N,N-diisopropylamine

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 18 from (Z)-3-[1-(4-carboxyphenylamino)-1-phenyl-methylidene]-2-indolinone, methylamine-hydrochloride, TBTU, HOBt and N-ethyl-N,N-diisopropylamine in DMF.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06855710B2uspto-grants-2005_02