Reaktion #53023

ord-df0f348b445e4dcf81f6c519dd17e131

Reaktionsgleichung

CCOC(=C1C(=O)N(C(C)=O)c2ccccc21)c1ccccc1
1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone
CCOC(=O)Cc1ccc(N)cc1
ethyl 4-aminophenylacetate
C1CCNCC1
piperidine
→
CCOC(=O)Cc1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1
(Z)-3-[1-(4-ethoxycarbonylmethyl-phenylamino)-1-phenyl-me-thylidene]-2-indolinone

Edukte

CCOC(=C1C(=O)N(C(C)=O)c2ccccc21)c1ccccc1
1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone
CCOC(=O)Cc1ccc(N)cc1
ethyl 4-aminophenylacetate
C1CCNCC1
piperidine

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 1 from 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone and ethyl 4-aminophenylacetate in DMF and subsequent treatment with piperidine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06855710B2uspto-grants-2005_02