Reaktion #53010

ord-48b6d2d452b74375a4e06cb6cdb23a9b

Reaktionsgleichung

CC(=O)N1C(=O)C(=C(Cl)c2ccccc2)c2ccccc21
1-acetyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone
COCc1cccc(N)c1.Cl
3-methoxymethyl-aniline-hydrochloride
[Na+].[OH-]
sodium hydroxide
→
COCc1cccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)c1
(Z)-3-[1-(3-methoxymethyl-phenylamino)-1-phenyl-methylidene]-2-indolinone

Edukte

CC(=O)N1C(=O)C(=C(Cl)c2ccccc2)c2ccccc21
1-acetyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone
COCc1cccc(N)c1.Cl
3-methoxymethyl-aniline-hydrochloride
[Na+].[OH-]
sodium hydroxide

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF
CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 2 from 1-acetyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone and 3-methoxymethyl-aniline-hydrochloride in THF and subsequent treatment with sodium hydroxide solution in methanol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06855710B2uspto-grants-2005_02