Reaktion #52999

Reaktionsgleichung

2,6-dichloro-4-aminobenzoic acid methyl ester

tetrabutylammonium tribromide

→

2,6-dichloro-3-bromo-4-aminobenzoic acid methyl ester

Ausbeute 139.4%

Lösungsmittel

CH2Cl2

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with satd
2. 2
   TrocknenNaHCO3 and brine, dried (Na2SO4)
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1:4)

Vorschrift

To a solution of 2,6-dichloro-4-aminobenzoic acid methyl ester (2.80 g) in CH2Cl2 (20 mL) at −10° C. was added a solution of tetrabutylammonium tribromide (6.94 g) in CH2Cl2 (30 mL) dropwise at −10° C. After 2 h, the mixture was warmed to room temperature, washed with satd. NaHCO3 and brine, dried (Na2SO4), filtered, and concentrated. The residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1:4) to yield 2,6-dichloro-3-bromo-4-aminobenzoic acid methyl ester (2.99 g) ESMS: m/z 298 (MH+).

Quelle