Reaktion #529886

Reaktionsgleichung

1,2-Epoxy-3-octadecyloxypropane

piperazine

potassium carbonate

chloroform

→

1-[2'-hydroxy-3'-octadecyloxypropyl]-piperazine

Lösungsmittel

dimethyl formamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   Sonstigeto leave a residue
3. 3
   FiltrationThe undissolved material is filtered in vacuo
4. 4
   Einengenthe filtrate is concentrated in vacuo
5. 5
   Sonstigepurified by chromatography
6. 6
   Sonstigedried in vacuo

Vorschrift

1,2-Epoxy-3-octadecyloxypropane (5.0 g, 15.3 mmol) is added to a mixture of piperazine (1.94 g, 22.5 mmol) and anhydrous potassium carbonate (100 mg) in dimethyl formamide (60 mL) over a 30 minute period under a nitrogen atmosphere. The resultant mixture is stirred at 80°-90° C. (oil bath temperature) for 48 hours. The reaction mixture is cooled to room temperature and concentrated in vacuo to leave a residue. The residue is stirred with chloroform (125 mL). The undissolved material is filtered in vacuo, and the filtrate is concentrated in vacuo, purified by chromatography and dried in vacuo to afford 1-[2'-hydroxy-3'-octadecyloxypropyl]-piperazine.

Quelle