Reaktion #52986

Reaktionsgleichung

3,5-dimethoxybenzyl alcohol

tert-butyl-diphenylsilyl chloride

imidazole

→

3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether

Ausbeute 87.9%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeDMF was evaporated
2. 2
   Sonstigethe residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20% )

Vorschrift

A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), tert-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DMF (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20% ) to yield 8.5 g of 3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether. ESMS: m/z 407 (MH+).

Quelle