Reaktion #52985

Reaktionsgleichung

(3,5-dimethoxy)phenylacetic acid

Et2O

LiAlH4

HCl

→

3,5-dimethoxy-4-(2-hydroxyethyl)benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe mixture was washed with H2O/EtOAc
2. 2
   Sonstigethe organic layer was separated
3. 3
   ExtraktionThe aqueous layer was extracted with EtOAc
4. 4
   TrocknenThe combined organic layers were dried (MgSO4)
5. 5
   Einengenconcentrated in vacuo

Vorschrift

A solution of (3,5-dimethoxy)phenylacetic acid (3 g) in Et2O (100 mL) was cooled to 0° C. and LiAlH4 (1M in Et2O, 16.8 mL) was added. The mixture was warmed to room temperature and stirred for 5 h, whereupon the pH was adjusted to 5 using HCl (1 M). The mixture was washed with H2O/EtOAc and the organic layer was separated. The aqueous layer was extracted with EtOAc. The combined organic layers were dried (MgSO4) and concentrated in vacuo to give 3,5-dimethoxy-4-(2-hydroxyethyl)benzene (2.8 g) as a crude product.

Quelle