Reaktion #52984

Reaktionsgleichung

Thiomorpholine

3,5-dimethoxybenzyl chloride

→

3,5-dimethoxy-1-(thiomorpholino-methyl)benzene

Ausbeute 73.7%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solid material was removed by filtration
2. 2
   Sonstigethe filtrate was evaporated
3. 3
   SonstigeThe residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2)

Vorschrift

Thiomorpholine (3.4 g) was added to a solution of 3,5-dimethoxybenzyl chloride (2 g) in THF (25 mL) and the mixture was stirred overnight at room temperature. The solid material was removed by filtration and the filtrate was evaporated. The residue was purified by column chromatography (silica gel; eluent: EtOAc/hexane 1/2) to yield 2 g of 3,5-dimethoxy-1-(thiomorpholino-methyl)benzene. ESMS: m/z 253 (M).

Quelle