Reaktion #529760

Reaktionsgleichung

Methyl chloroformate

compound 3

4'-Hydroxy-4-biphenylcarboxylic acid

sodium hydroxide

hydrochloric acid

→

4'-Methoxycarbonyloxy-4-biphenylcarboxylic acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONDuring the addition a white precipitate
2. 2
   Sonstigewas formed
3. 3
   Filtrationthe resultant voluminous white solid was filtered off
4. 4
   Waschenwashed with water until acid-free and
5. 5
   Trocknendried (phosphorus pentoxide) in vacuo

Vorschrift

Methyl chloroformate (12.90 g, 0.137 mol) was added dropwise, over 10 minutes, to a stirred, cooled (5° C.) solution of compound 3 (10.00 g, 0.047 mol) in sodium hydroxide (5.44 g, 0.136 mol) and water (150 ml). During the addition a white precipitate was formed and this stirred mixture was allowed to warm to room temperature overnight. The resultant mixture was carefully acidified (pH 5) with dilute hydrochloric acid and the resultant voluminous white solid was filtered off, washed with water until acid-free and dried (phosphorus pentoxide) in vacuo.

Quelle