Reaktion #529147

ord-ac132a5111bf4aa0895a31dfe88cfe61

Reaktionsgleichung

[Na]
sodium
Oc1cccc(-c2ccccc2)n1
2-hydroxy-6-phenylpyridine
N#Cc1ccc(O)nc1
5-cyano-2-hydroxypyridine
COc1ccnc(O)c1
2-hydroxy-4-methoxypyridine
Oc1cccc(CCc2ccccc2)n1
2-hydroxy-6-phenethylpyridine
Oc1nccc2ccccc12
1-hydroxyisoquinoline
Oc1ccccn1
2-hydroxypyridine
COC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C
benzyloxycarbonyl-L-valyl-L-valine methyl ester

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

When the sodium salt of 6-n-amyl-2-hydroxypyridine, 5-cyano-2-hydroxypyridine, 2-hydroxy-4-methoxypyridine, 2-hydroxy-6-phenylpyridine, 2-hydroxy-6-phenethylpyridine or 1-hydroxyisoquinoline is used in place of the sodium salt of 2-hydroxypyridine, the yields of benzyloxycarbonyl-L-valyl-L-valine methyl ester are 72, 83, 81, 76, 80 and 73%, respectively.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04043992uspto-grants-1977_08