Reaktion #52857

Reaktionsgleichung

ethyl 4-[(5,5-dimethyl-5,6-dihydro-naphthalen-8(7H)-one-2-yl)azo]benzoate

→

title compound

(+/−) Ethyl 4-[(5,5-dimethyl-8-hydroxy-8-carbethoxymethyl-5,6,7,8-tetrahydronaphth-2-yl)azo]benzoate

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenby washing with 2% of hydrochloric acid, water, 95% ethanol, acetone and anhydrous ether
2. 2
   Trocknendried in vacuum for several hours) in 6 ml of dry benzene
3. 3
   workup.ADDITIONwas slowly added
4. 4
   TemperaturThe resulting mixture was refluxed for 2 h
5. 5
   FiltrationThe precipitate was filtered through celite
6. 6
   Waschenthe filtrate was washed with cold 15% sulfuric acid
7. 7
   WaschenThe organic phase was washed with saturated sodium bicarbonate, brine
8. 8
   Trocknendried over Na2SO4
9. 9
   Filtrationfiltered
10. 10
    Einengenconcentrated
11. 11
    Sonstigeto give a red oil
12. 12
    SonstigePurification by flash chromatography (silica gel, 30% ethyl acetate in hexane)

Vorschrift

To a refluxing solution of zinc dust (0.15 g, 20 mesh, activated prior to use by washing with 2% of hydrochloric acid, water, 95% ethanol, acetone and anhydrous ether, then dried in vacuum for several hours) in 6 ml of dry benzene was slowly added a mixture of bromo ethyl acetate (0.082 ml, 0.74 mmol) and ethyl 4-[(5,5-dimethyl-5,6-dihydro-naphthalen-8(7H)-one-2-yl)azo]benzoate (Compound D10, 0.13 g, 0.371 mmol) in 6 ml of dry benzene. The resulting mixture was refluxed for 2 h then cooled to room temperature. The precipitate was filtered through celite and the filtrate was washed with cold 15% sulfuric acid. The organic phase was washed with saturated sodium bicarbonate, brine, dried over Na2SO4, filtered and concentrated to give a red oil. Purification by flash chromatography (silica gel, 30% ethyl acetate in hexane) afforded the title compound as a red oil.

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