Reaktion #528152

Reaktionsgleichung

ammonium hydroxide

sulfuric acid

nitric acid

2,4-diamino-6-ethyl-5-(4-chlorophenyl)pyrimidine

→

2,4-diamino-6-ethyl-5-(4-chloro-3-nitrophenyl)pyrimidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool to about 50° C.
2. 2
   Temperaturwhile maintaining the reaction mixture temperature at about 50°-53° C
3. 3
   workup.ADDITIONUpon completion of addition
4. 4
   Temperaturwhile still maintaining the reaction mixture temperature at about 50° C
5. 5
   TemperaturAfter this time, the reaction mixture was cooled
6. 6
   workup.ADDITIONpoured into ice
7. 7
   workup.STIRRINGwith stirring
8. 8
   FiltrationA precipitate was collected by filtration
9. 9
   Waschenrinsed with water
10. 10
    Sonstigedried

Vorschrift

Concentrated sulfuric acid, 90 mL, and 70% nitric acid, 90 mL, were stirred together during which time the mixture warmed to about 65° C. The mixture was allowed to cool to about 50° C., and 30.0 grams (0.12 mole) of 2,4-diamino-6-ethyl-5-(4-chlorophenyl)pyrimidine (commercially available) was added portionwise during a 45 minute period, while maintaining the reaction mixture temperature at about 50°-53° C. Upon completion of addition, the reaction mixture was stirred for one hour, while still maintaining the reaction mixture temperature at about 50° C. After this time, the reaction mixture was cooled and poured into ice. The resultant mixture was cooled further and, with stirring, was made basic with concentrated ammonium hydroxide. A precipitate was collected by filtration, rinsed with water and dried, yielding 35.4 grams of 2,4-diamino-6-ethyl-5-(4-chloro-3-nitrophenyl)pyrimidine, mp 220°-223° C., dec. The NMR spectrum was consistent with the proposed structure.

Quelle