Reaktion #52799

Reaktionsgleichung

chlorosulfonic acid

2-oxindole

→

5-chlorosulfonyl-2-oxindole

Ausbeute 50.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction temperature was maintained below 30° C. during the addition
2. 2
   workup.ADDITIONAfter the addition
3. 3
   Temperaturheated to 68° C.
4. 4
   workup.STIRRINGstirred an additional 1 hr
5. 5
   Temperaturcooled
6. 6
   WaschenThe precipitate was washed with water
7. 7
   Sonstigedried in a vacuum oven

Vorschrift

To a 100 mL flask charged with 27 mL of chlorosulfonic acid was slowly added 13.3 g of 2-oxindole. The reaction temperature was maintained below 30° C. during the addition. After the addition, the reaction mixture was stirred at room temperature for 1.5 hr, heated to 68° C. and stirred an additional 1 hr, cooled, and poured into water. The precipitate was washed with water and dried in a vacuum oven to give 11.0 g of 5-chlorosulfonyl-2-oxindole (50% yield) which was used without further purification.

Quelle