Reaktion #52796

Reaktionsgleichung

2-methoxyphenylboronic acid

5-bromo-2-fluoronitrobenzene

sodium carbonate

→

4-fluoro-2′-methoxy-3-nitrobiphenyl

Lösungsmittel

toluene

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was refluxed for 2 hours
2. 2
   Einengenconcentrated
3. 3
   Extraktionthe residue extracted twice with ethyl acetate
4. 4
   WaschenThe ethyl acetate layer was washed with water and brine
5. 5
   Sonstigedried
6. 6
   Einengenconcentrated
7. 7
   Sonstigeto give a dark green oil which

Vorschrift

Tetrakis(triphenylphosphine)palladium (1 g) was added to a mixture of 5 g of 2-methoxyphenylboronic acid, 6.6 g of 5-bromo-2-fluoronitrobenzene and 30 mL of 2 M sodium carbonate solution in 50 mL of toluene and 50 mL of ethanol. The mixture was refluxed for 2 hours, concentrated, and the residue extracted twice with ethyl acetate. The ethyl acetate layer was washed with water and brine, dried, and concentrated to give a dark green oil which solidified on standing to give crude 4-fluoro-2′-methoxy-3-nitrobiphenyl.

Quelle