Reaktion #527748

Reaktionsgleichung

hydrochloric acid

4-chlorobenzaldehyde

sodium hydroxide

methyl 1-methyl-2-oxocylopentanecarboxylate

→

methyl 3-(4-chlorobenzylidene)-1-methyl-2-oxocylopentanecarboxylate

Lösungsmittel

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was evaporated under reduced pressure
2. 2
   ExtraktionThe residue was extracted with ethyl acetate
3. 3
   WaschenThe organic layer was washed with water
4. 4
   Sonstigedried
5. 5
   SonstigeEthyl acetate was evaporated under reduced pressure
6. 6
   Sonstigeto obtain 25 g of an oily matter

Vorschrift

To a solution of 3.4 g of sodium hydroxide in 770 ml of water were added 15 g of methyl 1-methyl-2-oxocylopentanecarboxylate (prepared in Reference Example 1 hereinafter) and a solution of 13.5 g of 4-chlorobenzaldehyde in 800 ml of methanol, and the mixture was stirred for 5 hours at room temperature. The reaction mixture was neutralized with diluted hydrochloric acid and the solvent was evaporated under reduced pressure. The residue was extracted with ethyl acetate. The organic layer was washed with water and dried. Ethyl acetate was evaporated under reduced pressure to obtain 25 g of an oily matter.

Quelle