Reaktion #527658

Reaktionsgleichung

methyl iodide

1-[1-(2-chlorophenyl)cyclobutyl]-7-methoxy-1,2,3,4-tetrahydroisoquinoline oxalate

potassium carbonate

→

1-[1-(2-chloro-phenyl)cyclobutyl]-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Lösungsmittel

acetone

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent removed by evaporation
2. 2
   workup.ADDITIONWater was added
3. 3
   Extraktionthe mixture extracted with ether

Vorschrift

A solution of methyl iodide (0.5 g) in acetone (10 ml) was added dropwise to a stirred suspension of 1-[1-(2-chlorophenyl)cyclobutyl]-7-methoxy-1,2,3,4-tetrahydroisoquinoline oxalate (1.4 g prepared as described in Example RC11) and anhydrous potassium carbonate (3 g) in acetone (80 ml). The mixture was stirred at ambient temperature for 3.5 hours and the solvent removed by evaporation. Water was added and the mixture extracted with ether. The ether layer yielded 1-[1-(2-chloro-phenyl)cyclobutyl]-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline as an oil.

Quelle