Reaktion #527627

ord-9f2232de7f0748df8b4a53a5cc1f66ba

Reaktionsgleichung

O=C1C(Cc2ccncc2)c2ccccc2N1N1CCCCC1
product
O=C1C(Cc2ccncc2)c2ccccc2N1N1CCCCC1
1,3-dihydro-1-(1-piperidinyl)-3-(4-pyridinylmethyl)-2H-indol-2-one
[H-].[Na+]
sodium hydride
CCOC(=O)CBr
ethyl bromoacetate
→
CCOC(=O)CC1(Cc2ccncc2)C(=O)N(N2CCCCC2)c2ccccc21
1,3-dihydro-2-oxo-1-piperidinyl-3-(4-pyridinylmethyl)-2H-indol-3-acetic acid, ethyl ester

Edukte

—
product
O=C1C(Cc2ccncc2)c2ccccc2N1N1CCCCC1
product
O=C1C(Cc2ccncc2)c2ccccc2N1N1CCCCC1
1,3-dihydro-1-(1-piperidinyl)-3-(4-pyridinylmethyl)-2H-indol-2-one
[H-].[Na+]
sodium hydride
CCOC(=O)CBr
ethyl bromoacetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The product obtained from Example 23 could be reacted with sodium hydride and ethyl bromoacetate in a manner similar to Example 8 to render the product as an oil. Mass Spec. Calcd. for C22H25N3O4 :394 (M+H). Found: 394.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05519132uspto-grants-1996_05