Reaktion #527184

Reaktionsgleichung

10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine

4-[N-methyl-N-(2-methylbenzoyl)amino]benzoyl chloride

triethylamine

tetrahydrofuran

4-[N-methyl-N-(2-methylbenzoyl) amino]benzoyl chloride

triethylamine

→

crystals

Ausbeute 59.5%

N-[4-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)phenyl]-N-methyl-2-methylbenzamide

Ausbeute 59.5%

Lösungsmittel

water

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture stirred for 2 days
2. 2
   Extraktionextracted with dichloromethane
3. 3
   WaschenThe extract is washed with water, 1N HCl, 1N NaHCO3, brine
4. 4
   Trocknendried (Na2SO4)
5. 5
   FiltrationThe solution is filtered through a thin pad of hydrous magnesium silicate
6. 6
   SonstigeThe filtrate is evaporated in vacuo
7. 7
   Sonstigethe residue crystallized from dichloromethane-hexane

Vorschrift

A mixture of 0.27 g of 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine, 0.518 g of 4-[N-methyl-N-(2-methylbenzoyl)amino]benzoyl chloride, 0.182 g of triethylamine and 7 ml of tetrahydrofuran is stirred at room temperature for 3 hours. To the mixture is added 0.29 g of 4-[N-methyl-N-(2-methylbenzoyl) amino]benzoyl chloride and 0.10 g of triethylamine in 2 ml of dichloromethane and the mixture stirred for 2 days. The mixture is poured into water and extracted with dichloromethane. The extract is washed with water, 1N HCl, 1N NaHCO3, brine and dried (Na2SO4). The solution is filtered through a thin pad of hydrous magnesium silicate. The filtrate is evaporated in vacuo and the residue crystallized from dichloromethane-hexane to give 0.38 g of crystals, m.p. 168°-170° C.

Quelle