Reaktion #526844

Reaktionsgleichung

4-bromo-3-chloro-3,4,4-trifluorobutanal

1-chloro-1,2-dibromotrifluoroethane

ethyl vinyl ether

sodium hydrosulfite sodium bicarbonate

sodium chlorite hydrogen peroxide

→

4-bromo-3-chloro-3,4,4-trifluorobutanoic acid

Reaktionsbedingungen

Vorschrift

A one pot reaction of 1-chloro-1,2-dibromotrifluoroethane (VI) with ethyl vinyl ether in the presence of sodium hydrosulfite/sodium bicarbonate followed by oxidation of the intermediate, 4-bromo-3-chloro-3,4,4-trifluorobutanal (VII), without isolation, with sodium chlorite/hydrogen peroxide to give 4-bromo-3-chloro-3,4,4-trifluorobutanoic acid (VIII) in overall unexpected yields;

Quelle