Reaktion #526671

Reaktionsgleichung

2-acetamido-5-bromo-3-nitrobenzotrifluoride

→

2-amino-5-bromo-3-nitrobenzotrifluoride

Ausbeute 75.6%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed overnight
2. 2
   Extraktionit was extracted by ethyl acetate (2×3 mL)
3. 3
   TrocknenThe extract was dried over Mg2SO4
4. 4
   Sonstigeevaporated

Vorschrift

A mixture of 2-acetamido-5-bromo-3-nitrobenzotrifluoride (400 mg, 1.258 mmol) in concentrated HCl (3.5 mL) was refluxed overnight, then it was extracted by ethyl acetate (2×3 mL). The extract was dried over Mg2SO4 and evaporated to give 261 mg (75.6%) of 2-amino-5-bromo-3-nitrobenzotrifluoride. 1H NMR (CDCl3): δ6.663 (S, 2H); 7.825 (d, 1H, J=1.2 Hz); 8.487 (d, 1H, J=1.2 Hz).

Quelle